For the latest publications of this PI visit Adithya Sridhar – Amsterdam UMC
Sridhar, A. (Adithya) a.sridhar@amsterdamumc.nl
| Research line | Pediatric Viral Infectious Diseases |
|---|---|
| Research institute(s) | AR&D Amsterdam Institute for Immunology and Infectious Disease |
| Description | With the use of human organoid technology, researchers within OrganoVIR labs investigate the effects of picornaviruses, HIV, CMV and SARS-CoV2 on these models, to increase our understanding of the mechanism of disease in humans. |
| Seniors | • Renata Viera de Sa, postdoctoral researcher • Carlemi Calitz, postdoctoral researcher" |
| Projects | |
| GUTVIBRATIONS ( Gut Virus Brain Axis Technology in Organoid Science ) | Renata Viera de Sa , Carlemi Calitz, Joep Korsten and Eline Freeze develop a human-based organ-on-chip system that mimics the gut-brain axis. This model system will be crucial for studying diseases that impact both the gut and brain, such as viral diseases. |
| COMMUTE (COMORBIDITY MECHANISMS UTILIZED IN HEALTHCARE ) | Renata Viera de Sa investigates links between Covid-19 infections and neurodegenerative diseases such as Alzheimer's and Parkinson. |
| The MAGENTA project | Nina Johannesson and Gijs Afink focus on understanding the impact of cytomegalovirus (CMV) on the placenta during pregnancy with the use of human placenta organoid models. |
| The AVATAR project | Eline Freeze and Nina Johannesson use an in vitro human complex intestinal mucosa model to evaluate the effects of unprocessed, Holder pasteurized, and UV-C processed CMV negative and CMV positive human milk on the host cell transcriptome. The effects of HoP or UV-C processing techniques on the inhibition of CMV infection in this physiologically relevant intestinal mucosal model are evaluated. |
| The NOVICE multi-omics study | Julie van der Post studies Multi-omics in Neurological and Neurocognitive functioning in HIV infected children; NOVICE study, a case –control cohort. |
| The COMBAT Study | The Horizon 2020 funded (Advancing Pandemic Preparedness Innovative Multidisciplinary Strategies for COMBATing severe Dengue), (Amber Schotting) |
| CMV Brain Organoid Studies | Lance Mulder investigates the effect of CMV on human iPSC derived brain organoids. |
| TPI-PPP Allowance of TKI-LSH | (Pamela Capendale work on the project Focus-on-Virus: Picornavirus and HIV infection using a complex gut-brain model |
| ADVOCATE | Ines Garcia Rodriguez investigates advanced complexity in human derived organoid models for virology; PPP Allowance 2022 TKI Health-Holland |
| Research line | Development of human disease models |
|---|---|
| Research institute(s) | AR&D Amsterdam Institute for Immunology and Infectious Disease |
| Description | This research aims to establish human disease models for studying infectious diseases. Here, we use human stem cells to generated organotypic models of the human intestinal tract, human airway, and the central nervous system. These models are then used in the subsequent research lines for studying viral pathogenesis and antiviral testing. |
| Seniors | • Prof. Dr. Dasja Pajkrt, PI • Dr. Katja Wolthers, PI • Dr. Renata Vieira de Sá |
| Projects | |
| The GUTVIBRATIONS consortium | The GUTVIBRATIONS consortium is developing a next-generation gut-brain axis organ-on-chip. This multi-organ system will simulate the human body and provides an animal-free solution for modelling human diseases and pre-clinical drug development. |
| Research line | Understanding Dengue virus neuropathogenesis |
|---|---|
| Research institute(s) | AR&D Amsterdam Institute for Immunology and Infectious Disease |
| Description | Advanced technologies, such as a brain-on-chip model, will be used to study dengue's impact on the nervous system. |
| Seniors | • Prof. Dr. Dasja Pajkrt, PI |
| Projects | |
| The COMBAT initiative | Amber Schotting aims to develop scalable, affordable solutions to address the growing dengue epidemic as well as establish a pipeline for rapid response to future viral pandemics. |
| Research line | Drug repurposing for chronic intestinal viral infections |
|---|---|
| Research institute(s) | AR&D Amsterdam Institute for Immunology and Infectious Disease |
| Description | In this research, we use human intestinal organoids to test potential antivirals for patients suffering from chronic intestinal infections. Specifically, antiviral effects of clinically approved compounds is tested against patient isolated viruses in an human intestinal model. |
| Seniors | • Prof. Dr. Dasja Pajkrt, PI • Dr. Katja Wolthers, PI |
| Projects | |
Last edited: 05-03-2026