For the latest publications of this PI visit Anton van Kaam | Amsterdam UMC
Kaam, A.H.L.C. van (Anton) a.h.vankaam@amsterdamumc.nl
| Research line | Neonatal pulmonology |
|---|---|
| Department | Neonatology |
| Research Institute(s) | AR&D |
| Description | This research line aims to unravel the (patho)physiological principles of neonatal lung function and disease. In addition, it aims to improve treatment of neonatal lung disease, thereby reducing the risk long-term respiratory morbidity, especially bronchopulmonary dysplasia (BPD). To achieve these goals we investigate new lung function monitoring tools, test new modes of respiratory support and pharmacological interventions. For this we perform(ed) pre-clinical experimental studies, observational cohort studies, randomized controlled trials, working together with both national and international research groups. |
| Seniors | • Wes Onland (PI) • Minke van Tuijl (post-doc) • Martijn Miedema (post-doc) • Michelle Romijn (post-doc) |
| Projects | |
| The SOS BPD study | Rosemarie de Ridder investigates the optimal lower limit saturation in infants with established BPD. |
| The PRIDICT BPD study | Emma Baas investigates the discriminating accuracy of biomarkers in blood and exhaled breath for the prediction of BPD in a multicenter setting. |
| The BPD diagnosis study | Trix Kat investigates what is the optimal definition of BPD in an international collaboration. |
| The Long term follow-up of the SToPBPD trial | Moniek van de Loo investigates the long term outcomes of the placebo controlled trial of hydrocortisone in preterm infants. |
| The POLAR study | Martijn Miedema investigates if applying a dynamic incremental PEEP level improves pulmonary transition at birth. |
| A multiple hit model for BPD | Irene Lok investigates in a rat model which hits are most important in the development of BPD |
| Novel diagnostics in paediatric exercise induced dyspnoea | Pascal Keijzer conducts research on novel diagnostics in paediatric exercise induced dyspnoea |
| Research line | Neonatal control of breathing |
|---|---|
| Department | Neonatology |
| Research Institute(s) | AR&D |
| Description | This research line aims to unravel the (patho)physiological principles of control of breathing in preterm infants. In addition, it aims to improve treatment of abnormal control of breathing. To achieve these goals we investigate new lung function monitoring tools, test new modes of respiratory support and pharmacological interventions. We perform(ed) observational cohort studies and randomized controlled trials, working together with both national and international research groups. |
| Seniors | • Jeroen Hutten (PI) • Ruud van Leuteren (post-doc) • Frans de Jongh (post-doc) |
| Projects | |
| Transcutaneous diaphragmatic EMG to detect, classify and treat apnea of prematurity | Fabio Blom investigates transcutaneous diaphragmatic EMG to detect, classify and treat apnea of prematurity |
| The DOXAPRAM study | This international RCT (by Kelly Storm) investigates the efficacy and safety of Doxapram in the treatment of apnea of prematurity |
| Research line | Long-term outcome after preterm birth |
|---|---|
| Department | Neonatology |
| Research Institute(s) | AR&D |
| Description | This research line aims to identify risk factors for abnormal long-term outcome following preterm birth and use these risk factors to design prediction models. In addition, it aims to design and test new interventions to improve outcome of both children and their parents. |
| Seniors | • Aleid Leemhuis (post-doc) • Cornelieke Aarnoudse-Moens (post-doc) • Jaap Oosterlaan (PI) • Lotte Haverman (PI) • Raoul Engelbert (PI) |
| Projects | |
| The HIPPO study | Kirsten Muller investigates long-term outcome of infants and parents following exposure to stress factors during the admission to the neonatal intensive care |
| Long-term outcome and machine learning prediction following preterm birth | Menne van Boveninvestigates long-term outcome and machine learning prediction following preterm birth |
| Improving and extending the TOP program following preterm birth | Monique Fliermaninvestigates improving and extending the TOP program following preterm birth |
| Outcome in adolescents following preterm birth | TBD aims to assess the impact of preterm birth on the brain and lungs in adolescents. |
| Research line | Nutrition, gut health, growth, and metabolism in newborns |
|---|---|
| Department | Neonatology |
| Research Institute(s) | AR&D |
| Description | This research line aims to add the knowledge bank and improve neonatal care with regard to parenteral and enteral nutrition (clinically oriented), gastroenterology (incl microbiology and surgery), and basic nutritional science (e.g. organoids, human milk / donor milk quality). |
| Seniors | • Chris v/d Akker (post-doc) • Hans van Goudoever • Tim de Meij • Joep Derikx • Vanesa Muncan – Dijkstra • Wouter de Jonge |
| Projects | |
| The NEC model (Tygat) | Jing Chen works on enteral organoid research (NEC model) (Tytgat) and clinical NEC/microbiome/nutrition research questions |
| Early life nutrition | Jacqueline Muts investigates early life nutrition (quality of formula for late preterm and term infants and effects on growth and body composition) |
| Dolphin trial (RCT) (myself) | Nutritional supplement for preterm infants; participation in national multicenter trial. |
| FIT studies (myself) | 2RCT's country & local PI for pharmaceutical trial (oral insulin) in order to improve gastro-intestinal maturation and reduce NEC. |
| Human milk (myself) | Human milk (bank) research: Biobank research with milk (e.g. PFAS, iodine, chemotherapy) |
| Database (cohort) research (myself) | Database (cohort) research; e.g. effects of probiotics implementation, NEC cohort database description, post-surgery feeding, etc (partly in collaboration with Pediatric Gastroenterology Dpt and Pediatric Surgery Dpt). |
Last edited: 05-03-2026