For the latest publications of this PI visit Antonia Bouts – Amsterdam UMC
Bouts, A.H.M. (Antonia) a.h.bouts@amsterdamumc.nl
| Research line | LEARNS |
|---|---|
| Department | Pediatric nephrology |
| Research Institute(s) | AR&D Amsterdam Infection and Immunity |
| Description | This research line aims to prevent a relapse in children with first episode of idiopathic nephrotic syndrome (INS) and to unravel to pathogenesis of INS. The LEARNS consortium consists of 5 work packages: 1. RCT with combination treatment of prednisolone and levamisole or placebo. 2. Health-related Quality-of Life (HRQoL), 3. Pharmacokinetics and Pharmacodynamics of prednisolone and levamisole. 4. IMMUNOMICS and Biobanking. 5. In vitro podocytes research. |
| Seniors | • Antonia Bouts (PI) • Sandrine Florquin (immunopathologist) • Jeroen Guikema (immunologist) • Floor Veltkamp (postdoc) • Djera Khan (PhD) • Elske Mak (research nurse) • Ron Mathot (clinical pharmacist) • Lotte Haverman (psychologist / KLIK website) • Hedy van Oers (psychologist) • Susan Veissi (PhD Radboud UMC) • Michiel Schreuder (Radboud UMC) |
| Projects | |
| RCT | |
| HRQoL (KLIK website) | |
| PKPD | |
| Immunomics and Biobanking | |
| In vitro podocytes |
| Research line | Recurrence of nephrotic syndrome after pediatric kidney transplantation |
|---|---|
| Department | Pediatric nephrology |
| Research Institute(s) | AR&D Amsterdam Infection and Immunity |
| Description | Children with idiopathic steroid-resistant nephrotic syndrome (SRNS) have a high risk of developing end stage renal disease and recurrence after kidney transplantation. The treatment of recurrence is challenging. Within the European CERTAIN Working Group we investigates the recurrence rate, the (prophylactic) best treatment and outcome of children with SRNS/FSGS after kidney transplantation. |
| Seniors | • Antonia Bouts (PI) • Burkhard Toenshoff (Heidelberg, Germany) • Marina Vivarelli (Rome, Italy) • Priya Verghese (Chicago, USA) |
| Projects | |
| CERTAIN Registry analysis |
| Research line | TTV-TX |
|---|---|
| Department | Pediatric nephrology |
| Research Institute(s) | AR&D Amsterdam Infection and Immunity |
| Description | Torque Teno Virus (TTV) belongs to the Anelloviruses. The measurement of TTV in blood might be of additional value in the personalized dosing of immunosuppression in children after kidney transplantation, besides the blood concentration levels of immunosuppressive medication. A more personalized immunosuppressive treatment might prevent over- and under-immunosuppression with risk of rejection, infection and PTLD. Furthermore the Annelloma of the donor and recipient is investigated to study the transmission of the virus from donor to recipient. |
| Seniors | • Antonia Bouts (PI) • Mariet Feltkamp (virologist LUMC and Sanquin) • Lia van der Hoek (virologist, researcher AUMC • Luna Klomp (PhD) • Maarten Burggraaff (research analist AUMC) |
| Projects | |
| TTV qPCR in blood of pediatric kidney transplant recipient | |
| Anelloma of donor and recipient. |
Last edited: 05-03-2026