For the latest publications of this PI visit Clara van Karnebeek – Amsterdam UMC
Karnebeek, C.D. van (Clara) c.d.vankarnebeek@amsterdamumc.nl
| Research line | Pediatric chronic intestinal failure |
|---|---|
| Department | Pediatric metabolic diseases |
| Research Institute(s) | AR&D Amsterdam Gastroenterology Endocrinology Metabolism |
| Description | This research focuses on children with chronic intestinal failure and has the aim to better understand the complex underlying rare diseases, to improve nutritional management and catheter care, to improve transition from pediatric to adult care, to improve quality of life and to develop personalized medicine for children with rare congenital enteropathies. |
| Seniors | • M.M. Tabbers, PI • UD/UHD will start at May 1, 2025 In collaboration with Tytgat Institute for Liver and Intestinal Research and Emma Center for Personalized Medicine. • PI: Prof W. de Jonge, Prof S. van de Graaf, Dr. V. Dijkstra-Muncan, Prof C. van Karnebeek, Prof Joep Derikx, Prof. M. Serlie. |
| Projects | |
| Revestive monitor | Xavier Werner works on a prospective, observational, multicenter study to assess (cost)efficacy and safety of GLP-2 in children with short bowel syndrome. |
| Rivaroxoban in chronic intestinal failure | Xavier Werner and Samantha Gouw evaluate pharmacokinetics of rivaroxaban in children with chronic intestinal failure. |
| Essential fatty acid deficiency | Xavier Werner and Suzanne van Zundert investigate essential fatty acid deficiency and neurocognitive development of children with chronic intestinal failure on home parenteral nutrition |
| Nephropathology in children with chronic intestinal failure on home parenteral nutrition | Xavier Werner and Arend Bökenkamp investigate nephropathology in children with chronic intestinal failure on home parenteral nutrition: prospective, observational cohort study. |
| Pathogenesis of microvillous inclusion disease(UD/UHD) | Unraveling the pathogenesis of microvillous inclusion disease(UD/UHD): development of organoids |
| Microbiome and Tryptophan metabolites in children with intestinal failure +/- liver failure | Bruno Sovran and Annika Mutanen investigate microbiome and Tryptophan metabolites in children with intestinal failure +/- liver failure |
| Pediatric intestinal pseudo-obstruction syndrome in Europe | Annika Mutanen contributes to this prospective multicenter cohort study |
| Efficacy and safety of Taurolodine locks after GI surgery | Adinda Pijpers and Xavier Werner investigate the efficacy and safety of Taurolodine locks after GI surgery (a prospective observational study) |
| International Intestinal Failure registry | Xavier Werner contributes to this international, prospective registry for children with chronic intestinal failure on home parenteral nutrition |
| Optimal catheter care in children on Home PN | Michiel Lagerweij and Roel Bakx contribute to this prospective cohort study |
Last edited: 05-03-2026