For the latest publications of this PI visit Fanny Oliveira Arcolino – Amsterdam UMC
Oliveira Arcolino, F. (Fanny) f.oliveiraarcolino@amsterdamumc.nl
| Research line | Optimal and personalized treatment for patients with Primary Hyperoxaluria (PH) |
|---|---|
| Department | Pediatric nephrology |
| Research Institute(s) | Amsterdam Gastroenterology Endocrinology Metabolism |
| Description | Cystinosis is a genetic disorder affecting kidney function due to cystine accumulation. Current treatment with cysteamine slows progression but has many side effects. Our research suggests cystinosis-affected cells struggle to use cysteine for energy production. This project aims to stimulate this metabolic pathway using vitamins (vitamin B5 or vitamin B3) to improve energy metabolism in kidney cells. Using patient-derived cell models and advanced metabolic analysis, we study cystine and cysteine dynamics. Since vitamins are already available, our findings could quickly translate into improved patient treatment. |
| Seniors | • Fanny Oliveira Arcolino, Assistant Professor • Clara van Karnebeek, PI • Elena Levtchenko, PI • Fred Vaz, PI • Sante Princiero Berlingerio, Postdocoral researcher |
| Projects | |
Last edited: 05-03-2026