For the latest publications of this PI visit G.J. Hutten – Amsterdam UMC
Hutten, G.J. (Jeroen) g.j.hutten@amsterdamumc.nl
| Research line | Pediatric acute lung injury and respiratory support |
|---|---|
| Department | Neonatology |
| Research Institute(s) | AR&D |
| Description | This research line aims to determine the impact and treatment of acute lung injury in critically ill children. The work focuses on pathophysiological mechanisms and epidemiology of severe viral respiratory infections and ARDS, childhood respiratory trajectories, the effectiveness of various respiratory support modalities (e.g. mechanical ventilation and non-invasive ventilation), potential adverse effects of treatment (e.g. ventilator- and hyperoxia-induced lung injury), and opportunities for optimization of treatment (e.g. ventilation mask personalization). |
| Seniors | • David van Meenen, postdoctoral researcher • Dick Markhorst, postdoctoral researcher |
| Projects | |
| The MASK FIT Studies | Rosemijne Pigmans investigates personalization of pediatric ventilation masks by 3D scanning & printing |
| The PROVENT-PED Studies | Jonathan Melger and Relin van Vliet investigate global practice of pediatric ventilation and respiratory support |
| The POWER Studies | Thijs Lilien and Agnes Maas investigate chemical energy (power) transfer by hyperoxia treatment and mechanical ventilation. |
| The RHEOMUCUS Studies | Rosalie Linssen investigates biophysical properties of airway mucus in ICU patients |
| Research line | Pediatric acute lung injury and respiratory support |
|---|---|
| Department | Neonatology |
| Research Institute(s) | AR&D |
| Description | The research focuses on monitoring respiration in preterm infants using transcutaneous electromyography of the diaphragm (dEMG) and exploring treatments for apnea in preterm infants. This includes both bench studies and clinical trials. Over the past few years, dEMG has been validated as a reliable method for cardiorespiratory monitoring. Further investigations are underway to determine whether dEMG can be utilized to synchronize spontaneous breathing in preterm infants with ventilators. Additionally, the research examines the effects of hypoxia resulting from apnea and assesses the safety and efficacy of doxapram as a potential treatment for apnea in preterm infants. |
| Seniors | • Anton van Kaam, PI • Jeroen Hutten, PI • Ruud van Leuteren, postdoc |
| Projects | |
| Transcutaneous electromyography of the diaphragm as a novel triggering modality for non-invasive ventilation | Fabio Blom works on the project about transutaneous electromyography of the diaphragm as a novel triggering modality for non-invasive ventilation |
| The Doxa-trial | Kelly Storm contributes to this international double blinded multicenter randomized placebo controlled trial and investigates if doxapram is effective and safe in reducing the composite outcome (death or severe disability) of preterm infants at 2 years corrected age, as compared to placebo. Study Details | Doxapram Therapy in Preterm Infants (DOXA Trial) | ClinicalTrials.gov |
Last edited: 05-03-2026