For the latest publications of this PI visit Karin Fijnvandraat – Amsterdam UMC
Fijnvandraat, C.J. (Karin) c.j.fijnvandraat@amsterdamumc.nl
| Research line | Hemophilia and bleeding disorders |
|---|---|
| Department | Pediatric hematology |
| Research Institute(s) | AR&D |
| Description | Inhibitor development, ADA (anti drug antibodies): immunological and epidemiological determinants • Outcome measurement in hemophilia |
| Seniors | • Samantha Gouw, PI • Karin Fijnvandraat, PI • Jan Voorberg, (Sanquin/Landsteiner lab) PI |
| Projects | |
| The SPIRIT study | Liliane van Stam investigates the effect of non replacement therapy for hemophilia on immune tolerance towards FVIII |
| HEMONED EUHASS | Samantha Gouw coordinates HEMONED (pharmacovigilance and research registry of all Dutch hemophilia patients) and EUHASS (pharmacovigilance and research registry of all European hemophilia patients) |
| Proteomics in clotting | essica Delcastilho investigates roteomics in clotting |
| Tolerance in homophilia | Mariorosaria de Miranda investigates tolerance in hemophilia |
| Gene therapy VWD | Alistair Barraclough investigates gene therapy VWD |
| Sex and hemophilia | Tessa van Gastel investigates sex and hemophilia |
| The DosEMi study | National study on efficacy of lower doses of Hemlibra, coordinated by PhD from UMCU |
| The TINKIDS Study | National study on thrombocyte function disorders (coordinated by PhD from UMCU) |
| Research line | Pediatric trombosis |
|---|---|
| Department | Pediatric hematology |
| Research Institute(s) | AR&D |
| Description | The research line focuses on two topics: anticoagulation in children and long-term outcomes after thrombosis. In our anticoagulation research, we strive to determine the optimal dosage for children of, among other things, low-molecular-weight heparin, with the fewest side effects. We also investigate how to treat thrombosis as optimally as possible. This way, we aim to ensure that children have the best possible outcome from their thrombosis. In our long-term outcome studies, we examine the complications children develop with different types of thrombosis. A pulmonary embolism causes very different symptoms than a thrombosis in the leg. By accurately identifying the symptoms children experience after their thrombosis, and the risk factors for developing them, we can tailor follow-up to the anticipated problems for each child. |
| Seniors | • Irene Klaassen, Postdocoral researcher • Karin Fijnvandraat, PI |
| Projects | |
| SAFE NEO | Marieke Verweij investigates the pharmacokinetics and pharmacodynamics of nadroparin in neonates |
| SAFE KIDS | Marieke Verweij investigates the pharmacokinetics and pharmacodynamics of nadroparin in children |
| The ELF Study | Lotte de Boer investigates the role of lipoprotein (a) in venous thrombosis |
| The Adolescent Study | The Adolescent Study investigates optimal dosing regimens and long term outcomes of thrombosis in adolescents with venous thrombosis |
| Research line | Sickle Cell Disease |
|---|---|
| Department | Pediatric hematology |
| Research Institute(s) | AR&D |
| Description | This research line aims to reduce the burden of pain caused by Vaso Occlusive Episodes in Sickle Cell Disease by early identification and preventive interventions. The second domain of research in SCD is the effect of Sickle Cell Disease on the brain. |
| Seniors | • Cornelis van der Torren, Postdoctoral researcher • Karin Fijnvandraat, PI |
| Projects | |
| The RELAX Study | Mariana Nery contributes to this RCT to investigate the effect of EMDR in reducing Pain Interference in Sickle Cell Disease |
| The ONSET Study | Noa Ijdo tracks early neurocognitive development in infants with sickle cell disease using eyetracking |
| The BRICK study | Noa Ijdo contributes to this longitudinal cohort study that identifies the neuropsychological development as well as changes in brain imaging on MRI of children with SCD |
| The BEATS Study | Robin Rijnhout aims to use vital signs captured by wearables for the early detection of Vaso Occlusive Episodes |
| Research line | Transfusion in sickle cell disease and neonates |
|---|---|
| Department | Pediatric hematology |
| Research Institute(s) | Amsterdam Reproduction and Development |
| Description | This research line aims to improve transfusion practices in patients with SCD and neonates by analysing efficacy and safety of red blood cell and thrombocyte transfusions. |
| Seniors | • Suzanne Gunninkk, Postdocoral researcher • Karin Fijnvandraat, PI • Wes Onland, PI |
| Projects | |
| The SURVIVE Study | Lydian de Ligt) studies the determinants of heterogeneity in transfused Red Blood Cells as well as the role of the inflammasome |
| The IDEAL project | Yara Dixon studies burdens and facilitators of people of colour to become blood donors. Also the prevention of allo immunization by blood group genotyping is analysed. |
| The HEMOCURE | Hilde van der Staaij addresses several research questions regarding trombocyte transfusion in the NICU population |
| The INSPIRE project | Nina Houben addresses several research questions regarding trombocyte transfusion in the NICU population |
Last edited: 05-03-2026