| Description | Research Line | PI | |
|---|---|---|---|
| GUTVIBRATIONS ( Gut Virus Brain Axis Technology in Organoid Science ) | Renata Viera de Sa , Carlemi Calitz, Joep Korsten and Eline Freeze develop a human-based organ-on-chip system that mimics the gut-brain axis. This model system will be crucial for studying diseases that impact both the gut and brain, such as viral diseases. | Pediatric Viral Infectious Diseases | Adithya Sridhar |
| COMMUTE (COMORBIDITY MECHANISMS UTILIZED IN HEALTHCARE ) | Renata Viera de Sa investigates links between Covid-19 infections and neurodegenerative diseases such as Alzheimer's and Parkinson. | Pediatric Viral Infectious Diseases | Adithya Sridhar |
| The MAGENTA project | Nina Johannesson and Gijs Afink focus on understanding the impact of cytomegalovirus (CMV) on the placenta during pregnancy with the use of human placenta organoid models. | Pediatric Viral Infectious Diseases | Adithya Sridhar |
| The AVATAR project | Eline Freeze and Nina Johannesson use an in vitro human complex intestinal mucosa model to evaluate the effects of unprocessed, Holder pasteurized, and UV-C processed CMV negative and CMV positive human milk on the host cell transcriptome. The effects of HoP or UV-C processing techniques on the inhibition of CMV infection in this physiologically relevant intestinal mucosal model are evaluated. | Pediatric Viral Infectious Diseases | Adithya Sridhar |
| The NOVICE multi-omics study | Julie van der Post studies Multi-omics in Neurological and Neurocognitive functioning in HIV infected children; NOVICE study, a case –control cohort. | Pediatric Viral Infectious Diseases | Adithya Sridhar |
| The COMBAT Study | The Horizon 2020 funded (Advancing Pandemic Preparedness Innovative Multidisciplinary Strategies for COMBATing severe Dengue), (Amber Schotting) | Pediatric Viral Infectious Diseases | Adithya Sridhar |
| CMV Brain Organoid Studies | Lance Mulder investigates the effect of CMV on human iPSC derived brain organoids. | Pediatric Viral Infectious Diseases | Adithya Sridhar |
| TPI-PPP Allowance of TKI-LSH | (Pamela Capendale work on the project Focus-on-Virus: Picornavirus and HIV infection using a complex gut-brain model | Pediatric Viral Infectious Diseases | Adithya Sridhar |
| ADVOCATE | Ines Garcia Rodriguez investigates advanced complexity in human derived organoid models for virology; PPP Allowance 2022 TKI Health-Holland | Pediatric Viral Infectious Diseases | Adithya Sridhar |
| The GUTVIBRATIONS consortium | The GUTVIBRATIONS consortium is developing a next-generation gut-brain axis organ-on-chip. This multi-organ system will simulate the human body and provides an animal-free solution for modelling human diseases and pre-clinical drug development. | Development of human disease models | Adithya Sridhar |
| The COMBAT initiative | Amber Schotting aims to develop scalable, affordable solutions to address the growing dengue epidemic as well as establish a pipeline for rapid response to future viral pandemics. | Understanding Dengue virus neuropathogenesis | Adithya Sridhar |
| PROM4RARE | PhD candidateNadia van Silfhout focuses on development of generic PROMs for this patient population and validation for specific (syndromal) subgroups | PROs and PROMs for rare diseases | Agnies van Eeghen |
| GAS4RARE | PhD candidate Alannah Hijlkema focuses on validation of goal attainment scaling for this patient population | PROs and PROMs for rare diseases | Agnies van Eeghen |
| COS4TSC | PhD candidate Floortje Hosman is part of an international collaboration focusing on development and validation of a core outcome set for Tuberous Sclerosis Complex | PROs and PROMs for rare diseases | Agnies van Eeghen |
| PI of EPICOM | A multicenter CBD trial initiated and sponsored by Jazz pharmaceuticals | Trials for complex behavioral manifestations of genetic neurodevelopmental disorders | Agnies van Eeghen |
| CBD4RARE | PhD candidates Floortje Hosman and Kim van Veldhuizen collaborate to an N-of-1 trial with CBD for TSC, FXS and Sanfilippo | Trials for complex behavioral manifestations of genetic neurodevelopmental disorders | Agnies van Eeghen |
| TEAM Down | A prospective, observational study on effectiveness of SSRIs, lorazepam, and immunotherapy for depression and regression in Down Syndrome | Trials for complex behavioral manifestations of genetic neurodevelopmental disorders | Agnies van Eeghen |
| TEAM Down | Understanding bio-psycho-social factors associated with the course of depressive and regressive symptoms in Down syndrome | Trials for complex behavioral manifestations of genetic neurodevelopmental disorders | Agnies van Eeghen |
| Project IDEA | PhD candidate Hadassa Kwetsie investigates dementia and blood biomarkers in various genetic syndromes and a large patient population with ID and epilepsy. Also researching experiences and attitudes on postmortem investigations in (genetic) ID | Dementia in rare genetic neurodevelopmental disorders | Agnies van Eeghen |
| PI of Biomarkers4TSC | An international collaboration exploring blood biomarkers for neurodegeneration in Tuberous Sclerosis Complex | Dementia in rare genetic neurodevelopmental disorders | Agnies van Eeghen |
| Optimizing methodology for guidelines for rare genetic neurodevelopmental disorders | By PhD student Mirthe Klein-Haneveld | Guidelines for ERN ITHACA | Agnies van Eeghen |
| Development of guidelines for rare genetic neurodevelopmental disorders | With various international working groups | Guidelines for ERN ITHACA | Agnies van Eeghen |
| The QoL Study | QoL study in children and adults with homozygous FH | Familial Hypercholesterolemia | Albert Wiegman |
| Follow-up of a large cohort of adults who were diagnosed with FH as children | Sibbeliene van den Bosch conducts a follow-up of a large cohort of adults who were diagnosed with FH as children | Familial Hypercholesterolemia | Albert Wiegman |
| Cascade screening for high LP(a) | Sibbeliene van den Bosch studies cascade screening for high Lp(a) | Familial Hypercholesterolemia | Albert Wiegman |
| cIMT measurements in the doctor’s office | Sibbeliene van den Bosch and F. Kowsoleea investigate cIMT measurements in the doctor’s office | Familial Hypercholesterolemia | Albert Wiegman |
| Incidence of statin intolerance in childhood | Sibbeliene van den Bosch and F. Kowsoleea investigate the incidence of statin intolerance in childhood | Familial Hypercholesterolemia | Albert Wiegman |
| Long term effects | Marijn Arnoldussen studies long term effects | Strengthening Transgender Care for Adolescents | Annelou de Vries |
| Sexuality and communication | Sara Bungener studies sexuality and communication | Strengthening Transgender Care for Adolescents | Annelou de Vries |
| Gender developmental pathways | Frederique de Rooy studies gender developmental pathways | Strengthening Transgender Care for Adolescents | Annelou de Vries |
| Participatory action research, empowering the voice of the adolescent | Ezra Oosthoek studies participatory action research, empowering the voice of the adolescent | Strengthening Transgender Care for Adolescents | Annelou de Vries |
| Factors associated with young adult outcomes | Skye Stanwich investigates factors associated with young adult outcomes | Strengthening Transgender Care for Adolescents | Annelou de Vries |
| intra country comparisons | Aisa Burgwal investigates intra country comparisons | Strengthening Transgender Care for Adolescents | Annelou de Vries |
| Uncertainty in consult communication | Casper Martens investigates uncertainty in consult communication | Strengthening Transgender Care for Adolescents | Annelou de Vries |
| Gender developmental pathways in prepubertal children | Anouk Smits investigates gender developmental pathways in prepubertal children | Strengthening Transgender Care for Adolescents | Annelou de Vries |
| Treatment outcomes on puberty blockers and hormones | Nina Pot investigates treatment outcomes on puberty blockers and hormones | Strengthening Transgender Care for Adolescents | Annelou de Vries |
| Autism characteristics and treatment pathways | Isa van Wieringen investigates autism characteristics and treatment pathways | Strengthening Transgender Care for Adolescents | Annelou de Vries |
| Sexuality in transgender adolescents receiving early medical intervention | Isabelle van der Meulen investigates sexuality in transgender adolescents receiving early medical intervention | Strengthening Transgender Care for Adolescents | Annelou de Vries |
| Availability and reimbursement of treatments for Urea Cycle Disorders | Nina Stolwijk investigates vailability and reimbursement of treatments for Urea Cycle Disorders | Medication for Inborn Errors of Metabolism | Annet Bosch |
| Defining essential nutrients for IEM | Nina Stolwijk defines essential nutrients for IEM | Medication for Inborn Errors of Metabolism | Annet Bosch |
| Evaluating effectiveness of riboflavin in IEM | Nina Stolwijk evaluates effectiveness of riboflavin in IEM | Medication for Inborn Errors of Metabolism | Annet Bosch |
| Effectiveness and safety of PLP in PNPO deficiency | Nina Stolwijk investigates evaluates effectiveness and safety of PLP in PNPO deficiency | Medication for Inborn Errors of Metabolism | Annet Bosch |
| Development on new international guideline for PKU (PKU Guidelines Group) | Development on new international guideline for PKU (PKU Guidelines Group) | PKU | Annet Bosch |
| Start of Phase III trial with new treatment | 2025: start of Phase III trial with new treatment | PKU | Annet Bosch |
| Participation in trial breastmilk feeding protocol in newborns with PKU | 2025: Nina Stolwijk participates in trial breastmilk feeding protocol in newborns with PKU | PKU | Annet Bosch |
| Klinische evaluatie van het 3-MCCD hielprikprogramma | Ryan Aukes is betrokken bij de klinische evaluatie van het 3-MCCD hielprikprogramma | Newborn Screening | Annet Bosch |
| Data mining study into undiagnosed patients | Bregje Jaeger contributes to the data mining study into undiagnosed patients | Riboflavin Transporter Deficiency | Annet Bosch |
| Evaluation of effectiveness of Riboflavin in patients with inborn errors of metabolism | Bregje Jaeger evaluates effectiveness of Riboflavin in patients with inborn errors of metabolism | Riboflavin Transporter Deficiency | Annet Bosch |
| Patient registry (Context of Metab ERN ECZA) | Bregje Jaeger contributes to patient registry (Context of Metab ERN ECZA) | Riboflavin Transporter Deficiency | Annet Bosch |
| Treatment optimization | Bregje Jaeger investigates treatment optimization | Riboflavin Transporter Deficiency | Annet Bosch |
| Omics studies into optimal biomarkers | Bregje Jaeger contributes to the omics studies into optimal biomarkers | Riboflavin Transporter Deficiency | Annet Bosch |
| The Elucidating Galactosemia studies | The Elucidating Galactosemia studies investigate metabolic processes and genetic dysregulation in a galactosemia cell model which was recently developed by us. At this time, the focus is on fluxomics and the study of lipid metabolism. | Classical Galactosemia | Annet Bosch |
| Revising the international Guidelines for Diagnosis and Follow Up of Classical galactosemia | On behalf of the Galactosemia Network and European Galactosemia Society Annet Bosch is in charge of revising the international Guidelines for Diagnosis and Follow Up of Classical galactosemia | Classical Galactosemia | Annet Bosch |
| Development of the European Care Pathway for Classical Galactosemia | On behalf of the European reference Network for Metabolic Diseases (Metab ERN) Annet Bosch is in charge of development of the European Care Pathway for Classical Galactosemia | Classical Galactosemia | Annet Bosch |
| The SOS BPD study | Rosemarie de Ridder) investigates the optimal lower limit saturation in infants with established BPD. | Neonatal pulmonology | Anton van Kaam |
| The PRIDICT BPD study | Emma Baas investigates the discriminating accuracy of biomarkers in blood and exhaled breath for the prediction of BPD in a multicenter setting. | Neonatal pulmonology | Anton van Kaam |
| The BPD diagnosis study | (Trix Katz) investigates what is the optimal definition of BPD in an international collaboration. | Neonatal pulmonology | Anton van Kaam |
| The Long term follow-up of the SToPBPD trial | (Moniek van de Loo) investigates the long term outcomes of the placebo controlled trial of hydrocortisone in preterm infants. | Neonatal pulmonology | Anton van Kaam |
| The POLAR study | Martijn Miedema investigates if applying a dynamic incremental PEEP level improves pulmonary transition at birth. | Neonatal pulmonology | Anton van Kaam |
| A multiple hit model for BPD | Irene Lok investigates in a rat model which hits are most important in the development of BPD | Neonatal pulmonology | Anton van Kaam |
| Novel diagnostics in paediatric exercise induced dyspnoea | Pascal Keijzer conducts research on novel diagnostics in paediatric exercise induced dyspnoea | Neonatal pulmonology | Anton van Kaam |
| Transcutaneous diaphragmatic EMG to detect, classify and treat apnea of prematurity | Fabio Blom investigates transcutaneous diaphragmatic EMG to detect, classify and treat apnea of prematurity | Neonatal control of breathing | Anton van Kaam |
| The DOXAPRAM study | This international RCT (by Kelly Storm) investigates the efficacy and safety of Doxapram in the treatment of apnea of prematurity | Neonatal control of breathing | Anton van Kaam |
| The HIPPO study | Kirsten Muller investigates long-term outcome of infants and parents following exposure to stress factors during the admission to the neonatal intensive care | Long-term outcome after preterm birth | Anton van Kaam |
| Long-term outcome and machine learning prediction following preterm birth | Menne van Boveninvestigates long-term outcome and machine learning prediction following preterm birth | Long-term outcome after preterm birth | Anton van Kaam |
| Improving and extending the TOP program following preterm birth | Monique Fliermaninvestigates improving and extending the TOP program following preterm birth | Long-term outcome after preterm birth | Anton van Kaam |
| Outcome in adolescents following preterm birth | TBD aims to assess the impact of preterm birth on the brain and lungs in adolescents. | Long-term outcome after preterm birth | Anton van Kaam |
| The NEC model (Tygat) | Jing Chen works on enteral organoid research (NEC model) (Tytgat) and clinical NEC/microbiome/nutrition research questions | Nutrition, gut health, growth, and metabolism in newborns | Anton van Kaam |
| Early life nutrition | Jacqueline Muts investigates early life nutrition (quality of formula for late preterm and term infants and effects on growth and body composition) | Nutrition, gut health, growth, and metabolism in newborns | Anton van Kaam |
| Dolphin trial (RCT) (myself) | Nutritional supplement for preterm infants; participation in national multicenter trial. | Nutrition, gut health, growth, and metabolism in newborns | Anton van Kaam |
| FIT studies (myself) | 2RCT's country & local PI for pharmaceutical trial (oral insulin) in order to improve gastro-intestinal maturation and reduce NEC. | Nutrition, gut health, growth, and metabolism in newborns | Anton van Kaam |
| Human milk (myself) | Human milk (bank) research: Biobank research with milk (e.g. PFAS, iodine, chemotherapy) | Nutrition, gut health, growth, and metabolism in newborns | Anton van Kaam |
| Database (cohort) research (myself) | Database (cohort) research; e.g. effects of probiotics implementation, NEC cohort database description, post-surgery feeding, etc (partly in collaboration with Pediatric Gastroenterology Dpt and Pediatric Surgery Dpt). | Nutrition, gut health, growth, and metabolism in newborns | Anton van Kaam |
| RCT | LEARNS | Antonia Bouts | |
| HRQoL (KLIK website) | LEARNS | Antonia Bouts | |
| PKPD | LEARNS | Antonia Bouts | |
| Immunomics and Biobanking | LEARNS | Antonia Bouts | |
| In vitro podocytes | LEARNS | Antonia Bouts | |
| CERTAIN Registry analysis | Recurrence of nephrotic syndrome after pediatric kidney transplantation | Antonia Bouts | |
| TTV qPCR in blood of pediatric kidney transplant recipient | TTV-TX | Antonia Bouts | |
| Anelloma of donor and recipient. | TTV-TX | Antonia Bouts | |
| Samen voor Complexe Gezinnen | Irma Hein and Christel Middeldorp aim to improve the collaboration between child and adolescent mental health care services and adult mental health care services for families treated at youth mental health care. | Family Mental health | Christel Middeldorp |
| Implementatie van zorg voor kinderen van ouders met psychische problematiek in de GGZ | Pauline Vahl and Christel Middeldorp focus on implementing the online program kopopouders.nl for parents that are treated in adult mental health care. | Family Mental health | Christel Middeldorp |
| Het gezin centraal in de jeugd-ggz | The project aims to get more insight into the prevalence of mental health problems in parents whose children are referred to child and youth mental health care and to screen parents for problems and refer them to a to be developed digital platform with self help modules to decrease their symptoms | Family Mental health | Christel Middeldorp |
| Analyses as part of several consortia (PRE-EMPT, R2D2, Youth GEMS) | As part of several international consortia (PRE-EMPT, R2D2, Youth GEMS), analyses are performed to predict outcomes in children presenting with mental health issues. These models include genetic data, parental mental health data and other demographic and clinical data. | Family Mental health | Christel Middeldorp |
| Revestive monitor | Xavier Werner works on a prospective, observational, multicenter study to assess (cost)efficacy and safety of GLP-2 in children with short bowel syndrome. | Pediatric chronic intestinal failure | Clara van Karnebeek |
| Rivaroxoban in chronic intestinal failure | Xavier Werner and Samantha Gouw evaluate pharmacokinetics of rivaroxaban in children with chronic intestinal failure. | Pediatric chronic intestinal failure | Clara van Karnebeek |
| Essential fatty acid deficiency | Xavier Werner and Suzanne van Zundert investigate essential fatty acid deficiency and neurocognitive development of children with chronic intestinal failure on home parenteral nutrition | Pediatric chronic intestinal failure | Clara van Karnebeek |
| Nephropathology in children with chronic intestinal failure on home parenteral nutrition | Xavier Werner and Arend Bökenkamp investigate nephropathology in children with chronic intestinal failure on home parenteral nutrition: prospective, observational cohort study. | Pediatric chronic intestinal failure | Clara van Karnebeek |
| Pathogenesis of microvillous inclusion disease(UD/UHD) | Unraveling the pathogenesis of microvillous inclusion disease(UD/UHD): development of organoids | Pediatric chronic intestinal failure | Clara van Karnebeek |
| Microbiome and Tryptophan metabolites in children with intestinal failure +/- liver failure | Bruno Sovran and Annika Mutanen investigate microbiome and Tryptophan metabolites in children with intestinal failure +/- liver failure | Pediatric chronic intestinal failure | Clara van Karnebeek |
| Pediatric intestinal pseudo-obstruction syndrome in Europe | Annika Mutanen contributes to this prospective multicenter cohort study | Pediatric chronic intestinal failure | Clara van Karnebeek |
| Efficacy and safety of Taurolodine locks after GI surgery | Adinda Pijpers and Xavier Werner investigate the efficacy and safety of Taurolodine locks after GI surgery (a prospective observational study) | Pediatric chronic intestinal failure | Clara van Karnebeek |
| International Intestinal Failure registry | Xavier Werner contributes to this international, prospective registry for children with chronic intestinal failure on home parenteral nutrition | Pediatric chronic intestinal failure | Clara van Karnebeek |
| Optimal catheter care in children on Home PN | Michiel Lagerweij and Roel Bakx contribute to this prospective cohort study | Pediatric chronic intestinal failure | Clara van Karnebeek |
| The NOVICE cohort | Julie van der Post and Ben van Nieuwland investigate the long term neurological, neurocognitive, cardiovascular outcomes of children and adolescents born with HIV | Pediatrische InfectieZiekte Onderzoek, PIZO | Dasja Pajkrt |
| The perinatal HIV cohort | Annouschka Weijsenfeld investigates the long term societal, behavioral and human health outcomes of children and adolescents born with HIV | Pediatrische InfectieZiekte Onderzoek, PIZO | Dasja Pajkrt |
| The iCMV study | Jason van Genderen investigates the long term neurological and neurocognitive, outcomes of children born with CMV | Pediatrische InfectieZiekte Onderzoek, PIZO | Dasja Pajkrt |
| The GUTVIBRATIONS ( Gut Virus Brain Axis Technology in Organoid Science ) project | Renata Viera de Sa, Carlemi Calitz, Joep Korsten and Eline Freeze develop a human-based organ-on-chip system that mimics the gut-brain axis. This model system will be crucial for studying diseases that impact both the gut and brain, such as viral diseases. | Pediatric Viral Infectious Diseases | Dasja Pajkrt |
| The COMMUTE (COMORBIDITY MECHANISMS UTILIZED IN HEALTHCARE ) project | Renata Viera de Sa investigates links between Covid-19 infections and neurodegenerative diseases such as Alzheimer's and Parkinson | Pediatric Viral Infectious Diseases | Dasja Pajkrt |
| The MAGENTA project | Nina Johannesson,and Gijs Afink focus on understanding the impact of cytomegalovirus (CMV) on the placenta during pregnancy with the use of human placenta organoid models. | Pediatric Viral Infectious Diseases | Dasja Pajkrt |
| The AVATAR project | Eline Freeze and Nina Johannesson) use an in vitro human complex intestinal mucosa model to evaluate the effects of unprocessed, Holder pasteurized, and UV-C processed CMV negative and CMV positive human milk on the host cell transcriptome. The effects of HoP or UV-C processing techniques on the inhibition of CMV infection in this physiologically relevant intestinal mucosal model are evaluated. | Pediatric Viral Infectious Diseases | Dasja Pajkrt |
| The NOVICE multi-omics study | Julie van der Post contributes to this case –control cohort about multi-omics in Neurological and Neurocognitive functioning in HIV infected children | Pediatric Viral Infectious Diseases | Dasja Pajkrt |
| The COMBAT study | Amber Schotting investigates Advancing Pandemic Preparedness Innovative Multidisciplinary Strategies for COMBATing severe Dengue | Pediatric Viral Infectious Diseases | Dasja Pajkrt |
| The CMV Brain Organoid Studies | Lance Mulder investigates the effect of CMV on human iPSC derived brain organoids. | Pediatric Viral Infectious Diseases | Dasja Pajkrt |
| TPI-PPP Allowance of TKI-LSH: Focus-on-Virus: Picornavirus and HIV infection using a complex gut-brain model | Pamela Capendal contributes to the project TPI-PPP Allowance of TKI-LSH: Focus-on-Virus: Picornavirus and HIV infection using a complex gut-brain model | Pediatric Viral Infectious Diseases | Dasja Pajkrt |
| The ADVOCATE model | Ines Garcia Rodrigue investigates advanced complexity in human derived organoid models for virology; (PPP Allowance 2022 TKI Health-Holland) | Pediatric Viral Infectious Diseases | Dasja Pajkrt |
| The GUTVIBRATIONS consortium | The consortium is developing a next-generation gut-brain axis organ-on-chip. This multi-organ system will simulate the human body and provides an animal-free solution for modelling human diseases and pre-clinical drug development | Development of human disease models | Dasja Pajkrt |
| The COMBAT initiative | Amber Schotting aims to develop scalable, affordable solutions to address the growing dengue epidemic as well as establish a pipeline for rapid response to future viral pandemics. | Understanding Dengue virus neuropathogenesis | Dasja Pajkrt |
| The NOGBS study | Marleen Groenveld contributes to this study 1) to investigate the clinical presentation, risk factors, and outcomes following GBS and E. coli infections in children under 3 months of age in the Netherlands, 2) to determine the genetic properties of the GBS bacterium that contribute to disease severity. 3) to compare protective antibodies against GBS among patients, healthy controls, and their mothers. This research will contribute to the further development of GBS vaccines | Paediatric IBD with focus on nutritional therapy | Douwe Visser |
| IPACE-KIDS | Nina Groeneveld improves the causal diagnosis in patients suspected of neurological infections | Paediatric IBD with focus on nutritional therapy | Douwe Visser |
| EOScalcNL | Sanne Janssen (Erasmus MC) contributes to this tailor-made Dutch neonatal early-onset sepsis calculator: towards precision medicine at birth | Paediatric IBD with focus on nutritional therapy | Douwe Visser |
| Immunogenicity and Safety Assessment of an Earlier Prime and Boost Measles Vaccination Schedule in High Burden setting | Gerald Businge (Uganda) contributes to Immunogenicity and Safety Assessment of an Earlier Prime and Boost Measles Vaccination Schedule in High Burden setting | Paediatric IBD with focus on nutritional therapy | Douwe Visser |
| Junyu Chen, together with KU Leuven | Stem cell therapy for kidney disease | Elena Levtchenko | |
| Sara Akalay, together with KU Leuven | Stem cell therapy for kidney disease | Elena Levtchenko | |
| The ArtDECO project | Lisanne Vendrig investigates the aetiology of renal and urinary tract anomalies defines diagnostic efficacy and clinical outcome | ArtDECO – Aetiology of renal and urinary tract anomalies defines diagnostic efficacy and clinical outcome | Elena Levtchenko |
| The FINEart project | Luna Klomp contributes to foetal INvestigations into the Etiology of anomalies of renal tissue | FINEart – Foetal INvestigations into the Etiology of anomalies of renal tissue | Elena Levtchenko |
| Optimal and personalized treatment for patients with Primary Hyperoxaluria (PH) | Laila Oubram and Lisa Deesker contribute to optimal and personalized treatment for patients with Primary Hyperoxaluria (PH) | Optimal and personalized treatment for patients with Primary Hyperoxaluria (PH) | Elena Levtchenko |
| The Quality of Life Study | Andit Braghmandita investigates the quality of life and the outcome of children with cancer in Indonesia | Global Pediatric Oncology | Gertjan Kaspers |
| The Supportive Care Study | Alexandra Pangarso studies the late effects and palliative care for children with cancer in Indonesia. | Global Pediatric Oncology | Gertjan Kaspers |
| The Epidemiology Study | Sari Nur Melani researches a national childhood cancer registry and clinical outcomes in Indonesia. | Global Pediatric Oncology | Gertjan Kaspers |
| The Malawi Study | George Chagaluka explores improved care for children with cancer in Malawi. | Global Pediatric Oncology | Gertjan Kaspers |
| The Follow-Up Study | Susan Mageto studies challenges in follow-up children with cancer in Kenya after completion of treatment in Kenya. | Global Pediatric Oncology | Gertjan Kaspers |
| The Awareness Study | Lillian Osamong investigates possibilities to improve the awareness about childhood cancer among the primary healthcare workers in Kenya. | Global Pediatric Oncology | Gertjan Kaspers |
| The CICERO Study | Sterre Schoon studies several aspects of childhood cancer in Sub-Sahara Africa, including treatment adherence in children with acute lymphoblastic leukemia. | Global Pediatric Oncology | Gertjan Kaspers |
| The Epidemiology and Mapping Study | Ibrahim El Salih investigates the challenges to initiate data registries in several hospitals in Sub-Sahara Africa and Indonesia, as well as differences in the incidence of childhood cancer in different geographical regions. | Global Pediatric Oncology | Gertjan Kaspers |
| The Early Referral Study | Larissa Klootwijk studies the possibilities to improve the process of referral of children with (suspected) cancer in Kenya. | Global Pediatric Oncology | Gertjan Kaspers |
| The Late Effects Study | Jesse Lemmen investigates the occurrence of late effects in childhood cancer survivors in Kenya as well as the possibility to develop and implement a follow-up schedule. | Global Pediatric Oncology | Gertjan Kaspers |
| The childhood AML Study | Romy van Weelderen investigated the outcome for children with AML in Kenya and possibilities to improve risk-group adapted treatment for children with AML in countries with ‘unlimited’ resources. | Childhood acute myeloid leukemia | Gertjan Kaspers |
| The Pro-TEICO Study | Noa Wijnen investigates the safety and efficacy of prophylactic i.v. teicoplanin to avoid invasive bloodstream infections caused by streptococci and other micro-organisms. It is a multi-center, multinational study. | Childhood acute myeloid leukemia | Gertjan Kaspers |
| The Morbidity and Mortality Study | Emily Schwartz determines quality of life during and after treatment for acute leukemias, and for AML specifically also toxicity of treatment including treatment-induced mortality. | Childhood acute myeloid leukemia | Gertjan Kaspers |
| The CHIP-AML Study | Merlijn van Hamel contributes to this multicenter, multinational clinical phase II/III trial aiming to improve outcome in children with newly diagnosed, initial AML. Improvements in terms of higher event-free survival, but also better quality-of-life and less unnecessary morbidity | Childhood acute myeloid leukemia | Gertjan Kaspers |
| The MASK FIT Studies | Rosemijne Pigmans investigates personalization of pediatric ventilation masks by 3D scanning & printing | Pediatric acute lung injury and respiratory support | Jeroen Hutten |
| The PROVENT-PED Studies | Jonathan Melger and Relin van Vliet investigate global practice of pediatric ventilation and respiratory support | Pediatric acute lung injury and respiratory support | Jeroen Hutten |
| The POWER Studies | Thijs Lilien and Agnes Maas investigate chemical energy (power) transfer by hyperoxia treatment and mechanical ventilation. | Pediatric acute lung injury and respiratory support | Jeroen Hutten |
| The RHEOMUCUS Studies | Rosalie Linssen investigates biophysical properties of airway mucus in ICU patients | Pediatric acute lung injury and respiratory support | Jeroen Hutten |
| Transcutaneous electromyography of the diaphragm as a novel triggering modality for non-invasive ventilation | Fabio Blom works on the project about transutaneous electromyography of the diaphragm as a novel triggering modality for non-invasive ventilation | Control of breathing in preterm infants | Jeroen Hutten |
| The Doxa-trial | Kelly Storm contributes to this international double blinded multicenter randomized placebo controlled trial and investigates if doxapram is effective and safe in reducing the composite outcome (death or severe disability) of preterm infants at 2 years corrected age, as compared to placebo. Study Details | Doxapram Therapy in Preterm Infants (DOXA Trial) | ClinicalTrials.gov | Control of breathing in preterm infants | Jeroen Hutten |
| The IMPALA Project | This project, performed by 7 international institutes, is aimed at developing an innovative vital signs monitor to timley identify deterioration of critically ill children. The monitor applies several innovative techniques including new sensors, artificial intelligence and robust and simple hard and software sollutions. Currently 4 PhD student, 3 MSc and 1 MMED student participate in this project. | Technical innovations to timely identify critically ill children | Job Calis |
| Big Data – Prediction modelling in paediatric critical care | William Nkhono (PhD-VU) contributes to the project Big Data – Prediction modelling in paediatric critical care. In collaboration with Mathematics VU dep of AI and Netherlands E-Health Learning Lab | Technical innovations to timely identify critically ill children | Job Calis |
| Patient monitoring for low-resource settings, social science approach | Daniel Mwale contributes to the project Patient monitoring for low-resource settings, social science approach. In collaboration with Amsterdam Institute for Global Health. | Technical innovations to timely identify critically ill children | Job Calis |
| Integration of AI and other models in clinical healthcare | Margot Rakers (PhD-LUMC) works on the project Integration of AI and other models in clinical healthcare. | Technical innovations to timely identify critically ill children | Job Calis |
| usability of a patient monitoring in a low-resource setting | Lezzie Chirambo (MSc MUBAS) works on the project usability of a patient monitoring in a low-resource setting | Technical innovations to timely identify critically ill children | Job Calis |
| (MSc MUBAS): Alarms, thresholds and predictive value | Christina Chiziwa (MSc MUBAS) works on the project Alarms, thresholds and predictive value | Technical innovations to timely identify critically ill children | Job Calis |
| Performance of early warning scores in Malawian HDU patients | James Makina (MMED KUHeS) works on the projects performance of early warning scores in Malawian HDU patients | Technical innovations to timely identify critically ill children | Job Calis |
| CISSAC Study | Roxanne Assies PhD UvA en Mercy Kumwenda MMED KUHeS) contribute to this combination of studies: a) new techniques (CRI and HRV) to identify children with shock b) new bedside Ultrasound protocol to type shock and c) a descriptive study about prevalence and characteristics of shock | Circulatory failure & Severe anaemia: | Job Calis |
| Validation of the new Phoenix Sepsis score in the PICU in Malawi | Charissa Verkade works on validation of the new Phoenix Sepsis score in the PICU in Malawi | Severe infectious diseases in paediatrics | Job Calis |
| Validation of CRP as a biomarker for bacteraemia and malaria in a hospitalized children with and without severe anaemia | Marijke Dorhoutmees works on the validation of CRP as a biomarker for bacteraemia and malaria in a hospitalized children with and without severe anaemia | Severe infectious diseases in paediatrics | Job Calis |
| The IMPALA project | Jacqueline Msefula and Margaret Havara investigate existing and novel biomarkers to distinguish bacterial, viral and malaria infection in Malawi | Severe infectious diseases in paediatrics | Job Calis |
| Health systems and development of paedi | Henderson Chitimoni investigates health systems and development of paediatric critical care in LRS | Setting up critical care units and care in LMIC | Job Calis |
| A set of studies on development and evaluation of training in paediatric critical care in LMIC | J Langton contributes to a set of studies on development and evaluation of training in paediatric critical care in LMIC | Setting up critical care units and care in LMIC | Job Calis |
| The MASK FIT Studies | Rosemijne Pigmans investigates personalization of pediatric ventilation masks by 3D scanning & printing | Pediatric acute lung injury and respiratory support | Job van Woensel |
| The PROVENT-PED Studies | Jonathan Melger and Relin van Vliet investigate global practice of pediatric ventilation and respiratory support | Pediatric acute lung injury and respiratory support | Job van Woensel |
| The POWER Studies | Thijs Lilien and Agnes Maas investigate chemical energy (power) transfer by hyperoxia treatment and mechanical ventilation. | Pediatric acute lung injury and respiratory support | Job van Woensel |
| The RHEOMUCUS Studies | Rosalie Linssen investigates biophysical properties of airway mucus in ICU patients | Pediatric acute lung injury and respiratory support | Job van Woensel |
| The LESSER 2 Study | Michiel Schwerzel tests whether restrictive fluid management in mechanically ventilated critically-ill children is superior to normal fluid | Respiratory insufficiency and mechanical ventilation | Job van Woensel |
| The MASK FIT Studies | Rosemijne Pigmans investigates personalization of pediatric ventilation masks by 3D scanning & printing | Respiratory insufficiency and mechanical ventilation | Job van Woensel |
| The PROVENT-PED Studies | Jonathan Melger and Relin van Vliet investigate global practice of pediatric ventilation and respiratory support | Respiratory insufficiency and mechanical ventilation | Job van Woensel |
| The POWER Studies | Thijs Lilien and Agnes Maas investigate chemical energy (power) transfer by hyperoxia treatment and mechanical ventilation. | Respiratory insufficiency and mechanical ventilation | Job van Woensel |
| Biophysical properties of airway mucus in ICU patients | Thijs Lilien and Agnes Maas investigate biophysical properties of airway mucus in ICU patients | Respiratory insufficiency and mechanical ventilation | Job van Woensel |
| The MACU PICU Study | Sarah van den Berg investigates different phenotypes of pediatric severe asthma making use of clinical parameters, metabolomics and breatheomics | Respiratory insufficiency and mechanical ventilation | Job van Woensel |
| The PATHS consortium | Berber Kapitein and consortium partners focus on the socioeconomic influences on the development of severe acute asthma (partners: Amsterdam health and Technology Institute, CBS, GGD Amsterdam and Gemeente Amsterdam) | Respiratory insufficiency and mechanical ventilation | Job van Woensel |
| The PICNIC Study | Barbara Geven investigates the role of early mobilization in criticially ill children admitted to the PICUed | Evidence for nursing practice | Job van Woensel |
| The BLADDER scan study | Anita de Jong aims to investigate the accuracy of the bladderscan in children | Evidence for nursing practice | Job van Woensel |
| The SleePICU studie | Barbara Geven and Marieke Otten will evaluate the implementation process of the sleep promotion bundle and investigate its short- and long-term effects on sleep quality, the incidence of delirium, and post-traumatic stress in both children and their parents | Evidence for nursing practice | Job van Woensel |
| Pulmonary Function | Laura Schoutenworks on an assessment of long-term respiratory outcomes and riskfactors in children who were on mechanical ventilation during their PICU stay | Longterm follow up critical illness | Job van Woensel |
| Cardiac Function | Nikki Schoenmaker evaluates of myocardial function and riskfactors 3–6 months post-PICU discharge in children treated with inotropic support | Longterm follow up critical illness | Job van Woensel |
| Neurocognitive functioning | Lidwien Tjaden will assess neurocognitive functioning using standardized questionnaires and neuropsychological assessments (NPO). Risk factors will be evaluated and outcomes will be compared with matched healthy controls | Longterm follow up critical illness | Job van Woensel |
| The BIOMODEM project | Biomarker/BioSensor development using Modulife to achieve intestinal healing in Maintenance of Remission in Crohn’s disease | Paediatric IBD with focus on nutritional therapy | Johan van Limbergen |
| PARADISE | CDED vs budesonide/prednison for induction of remission in mild-to-moderate Crohn’s disease | Paediatric IBD with focus on nutritional therapy | Johan van Limbergen |
| Ulcerative colitis: nutritional needs assessment | Ulcerative colitis: nutritional needs assessment | Paediatric IBD with focus on nutritional therapy | Johan van Limbergen |
| PIBD-Nuts | Nutritional screening IBD patients (main site: Glasgow University) | Paediatric IBD with focus on nutritional therapy | Johan van Limbergen |
| Nutri-IBD | Observational study biomarkers of crohn’s disease (main site: Weizmann Institute) | Paediatric IBD with focus on nutritional therapy | Johan van Limbergen |
| Ulcerative colitis: nutritional needs assessment | Industry-sponsored research UC / CD: Upadacitinib, mirikizumab, risankizumab | Paediatric IBD with focus on nutritional therapy | Johan van Limbergen |
| The SPIRIT study | Liliane van Stam investigates the effect of non replacement therapy for hemophilia on immune tolerance towards FVIII | Hemophilia and bleeding disorders | Karin Fijnvandraat |
| HEMONED EUHASS | Samantha Gouw coordinates HEMONED (pharmacovigilance and research registry of all Dutch hemophilia patients) and EUHASS (pharmacovigilance and research registry of all European hemophilia patients) | Hemophilia and bleeding disorders | Karin Fijnvandraat |
| Proteomics in clotting | essica Delcastilho investigates roteomics in clotting | Hemophilia and bleeding disorders | Karin Fijnvandraat |
| Tolerance in homophilia | Mariorosaria de Miranda investigates tolerance in hemophilia | Hemophilia and bleeding disorders | Karin Fijnvandraat |
| Gene therapy VWD | Alistair Barraclough investigates gene therapy VWD | Hemophilia and bleeding disorders | Karin Fijnvandraat |
| Sex and hemophilia | Tessa van Gastel investigates sex and hemophilia | Hemophilia and bleeding disorders | Karin Fijnvandraat |
| The DosEMi study | National study on efficacy of lower doses of Hemlibra, coordinated by PhD from UMCU | Hemophilia and bleeding disorders | Karin Fijnvandraat |
| The TINKIDS Study | National study on thrombocyte function disorders (coordinated by PhD from UMCU) | Hemophilia and bleeding disorders | Karin Fijnvandraat |
| SAFE NEO | Marieke Verweij investigates the pharmacokinetics and pharmacodynamics of nadroparin in neonates | Pediatric trombosis | Karin Fijnvandraat |
| SAFE KIDS | Marieke Verweij investigates the pharmacokinetics and pharmacodynamics of nadroparin in children | Pediatric trombosis | Karin Fijnvandraat |
| The ELF Study | Lotte de Boer investigates the role of lipoprotein (a) in venous thrombosis | Pediatric trombosis | Karin Fijnvandraat |
| The Adolescent Study | The Adolescent Study investigates optimal dosing regimens and long term outcomes of thrombosis in adolescents with venous thrombosis | Pediatric trombosis | Karin Fijnvandraat |
| The RELAX Study | Mariana Nery contributes to this RCT to investigate the effect of EMDR in reducing Pain Interference in Sickle Cell Disease | Sickle Cell Disease | Karin Fijnvandraat |
| The ONSET Study | Noa Ijdo tracks early neurocognitive development in infants with sickle cell disease using eyetracking | Sickle Cell Disease | Karin Fijnvandraat |
| The BRICK study | Noa Ijdo contributes to this longitudinal cohort study that identifies the neuropsychological development as well as changes in brain imaging on MRI of children with SCD | Sickle Cell Disease | Karin Fijnvandraat |
| The BEATS Study | Robin Rijnhout aims to use vital signs captured by wearables for the early detection of Vaso Occlusive Episodes | Sickle Cell Disease | Karin Fijnvandraat |
| The SURVIVE Study | Lydian de Ligt) studies the determinants of heterogeneity in transfused Red Blood Cells as well as the role of the inflammasome | Transfusion in sickle cell disease and neonates | Karin Fijnvandraat |
| The IDEAL project | Yara Dixon studies burdens and facilitators of people of colour to become blood donors. Also the prevention of allo immunization by blood group genotyping is analysed. | Transfusion in sickle cell disease and neonates | Karin Fijnvandraat |
| The HEMOCURE | Hilde van der Staaij addresses several research questions regarding trombocyte transfusion in the NICU population | Transfusion in sickle cell disease and neonates | Karin Fijnvandraat |
| The INSPIRE project | Nina Houben addresses several research questions regarding trombocyte transfusion in the NICU population | Transfusion in sickle cell disease and neonates | Karin Fijnvandraat |
| The PROM4RARE study | Nadia van Silfhout focusses on the development and validation of a core PRO and PROM set for individuals with rare genetic diseases associated with intellectual disability. | Patient Reported Outcome Measures | Lotte Haverman |
| The GPROM optimalisation study | Anouk Groenewegen investigates how the generic PROM set is used in clinical practice and how the implementation of the PROMs can be optimized. | Patient Reported Outcome Measures | Lotte Haverman |
| The SIMPATHIC-PROM study | Tom Steenbergen develops a generic core PRO and PROM set for individuals with rare neurological, neurometabolic and neuromuscular disorders to be used in a drug-repurposing trial within SIMPATHIC. | Patient Reported Outcome Measures | Lotte Haverman |
| Shared-Decision Making in Pediatric Physical Therapy | Selina Limmen focusses on the implementation of PROMs via the KLIK PROM portal in 12 pediatric physical therapy practices, to facilitate SDM. | Patient Reported Outcome Measures | Lotte Haverman |
| Identifying issues related to sexuality in men and young women with bleeding disorders | Tessa van Gastel contributes to the project focused on identifying issues related to sexuality in men and young women with bleeding disorders as well as validating a PROMIS questionnaire to assess these problems. | Patient Reported Outcome Measures | Lotte Haverman |
| The Cure4Life study | Esmee van Zon contributes to the PRO(M) set for parents of children with a chronic illness is developed, and qualitative research about impact of gene therapy | Patient Reported Outcome Measures | Lotte Haverman |
| The Inclusive PROMs study | Lisa Stikvoort focusses on the development and validation of comprehensible PROMs for people with low literacy, as well as validating PROMs in other languages for people with a non-native background. | Patient Reported Outcome Measures | Lotte Haverman |
| The PROMs for (speech)motor impairments study | Juliet Hondtong) focusses on the development and validation of relevant PROMs for people with severe (speech)motor impairments. | Patient Reported Outcome Measures | Lotte Haverman |
| Validation of a PROM set for Pediatric Physical Therapy | Dorinde Korteling focuses on the validation of PROMIS in pediatric physical therapy. | Patient Reported Outcome Measures | Lotte Haverman |
| The use and validation of PROMIS for adults with sickle cell disease | Aida Kidane contributes to this project on the use and validation of PROMIS for adults with sickle cell disease | Patient Reported Outcome Measures | Lotte Haverman |
| The use and validation of PROMIS within pediatric oncology | Anne Westerweel contributes to this project on the use and validation of PROMIS within pediatric oncology | Patient Reported Outcome Measures | Lotte Haverman |
| The Project Opmaat naar Zorg op Maat | Mana Nasorii maps the barriers and facilitators of interprofessional collaboration, with parents as experts, in the care of individuals with rare genetic intellectual disabilities and challenging behavior. | Pediatric Psychology | Lotte Haverman |
| The IPE-C project | Franka Roestt) focuses on interprofessional collaboration in a Transitional Care Unit (Het Jeroen Pit Huis) to ultimately develop a targeted faculty development program and a framework for a continuous care evaluation model | Pediatric Psychology | Lotte Haverman |
| The HIPPO Study | Kirsten Muller examines the short- and long-term effects of neonatal and parental stress during NICU admission on child development and parental wellbeing in preterm infants born with a gestational age of less than 29 weeks. | Pediatric Psychology | Lotte Haverman |
| The effect of brief EMDR treatment for parents | Esmee Vesseur investigates the effect of brief EMDR treatment for parents —delivered both face-to-face and online—on reducing stress symptoms in parents of chronically ill children. | Pediatric Psychology | Lotte Haverman |
| Exploring the effectiveness of EMDR to reduce pain interference in children with sickle cell disease | Mariana Nery works on a study exploring the effectiveness of EMDR to reduce pain interference in children with sickle cell disease | Pediatric Psychology | Lotte Haverman |
| The HIPPO Study | The HIPPO Study examines the short- and long-term effects of neonatal and parental stress during NICU admission on child development and parental wellbeing in preterm infants born with a gestational age of less than 29 weeks. | Long term child and parental outcomes after perinatal problems | Lotte Haverman |
| The NWZ Follow-Up study | The NWZ Follow-Up study examines long-term outcomes at 2 and 9 years of children born at 32-37 weeks of gestation. | Long term child and parental outcomes after perinatal problems | Lotte Haverman |
| The AMICA-5-study | The AMICA-5-study: fAMily Integrated CAre (AMICA-study) in the neonatal ward: 5-year follow up the AMICA children | Long term child and parental outcomes after perinatal problems | Lotte Haverman |
| Constipation | Julia van de Zande, Michelle Bloem, Charlotte Jonker, Anna de Geus and Tirza van Os study constipation | Pediatric Gastroenterology | Marc Benninga |
| Abdominal pain | Koen Vermeijden, Anna Oorthuys and Jip Groen study Abdominal pain | Pediatric Gastroenterology | Marc Benninga |
| Neonatal sepsis | Jip Groen studies neonatal sepsis | Pediatric Gastroenterology | Marc Benninga |
| MAFLD | Anne-Sophie Stroes investigates MAFLD | Pediatric Gastroenterology | Marc Benninga |
| IBD and ultrasound | Hannah Vos investigates IBD and ultrasound | Pediatric Gastroenterology | Marc Benninga |
| Achalasia | Carlijn Mussies investigates Achalasia | Pediatric Gastroenterology | Marc Benninga |
| Intestinal Failure | Xavier Werner investigates intestinal failure | Pediatric Gastroenterology | Marc Benninga |
| ATTACK-GD3 trial | Kim van Veldhuizen investigates ... | ATTACK-GD3 trial; investigator initiated intervention study | Marion Brands |
| Sanfilippo syndrome, MPS III | Kim van Veldhuizen investigates ... | Sanfilippo syndrome, MPS III | Marion Brands |
| Gyrate Atrophy of the Choroid and Retina | Shihui Zeng investigates | Gyrate Atrophy of the Choroid and Retina | Marion Brands |
| Longterm follow-up of patients with Fabry disease | Bram Veldman contributes to this bservational studies in Fabry patients | Longterm follow-up of patients with Fabry disease | Marion Brands |
| The HEADLINE Study | Marloes Hoppen investigates the acute impact of heading in amateur football using blood biomarkers. | Neuroscientic outcome measurement | Marsh Königs |
| The PEPR Study | Cece Kooper determines neurodevelopmental outcome of traumatic brain injury in a research network of hospitals using neurocognitive testing, EEG and advanced multimodal MRI. " | Neuroscientic outcome measurement | Marsh Königs |
| The ONSET Study | Noa Ijdo tracks early neurocognitive development in infants using with sickle cell disease using eyetracking (Noa Ijdo) | Neuroscientic outcome measurement | Marsh Königs |
| The MATURE Study | Dook Koch investigates the long term outcome of meningitis among young adults infected in childhood using neurocognitive testing and advanced multimodal MRI. | Neuroscientic outcome measurement | Marsh Königs |
| The INPACT Study | Sophie Lijdsman investigates the impact of chronic kidney disease and associated treatments on the brain of children and young adults using neurocognitive testing, EEG and diffusion tensor imaging. | Neuroscientic outcome measurement | Marsh Königs |
| The Extubation Success Prediction study | Frank Bennis develops a machine learning model using routine clinical data and device data that provides online predictions of extubation success for children on mechanical ventilation at the Pediatric Intensive Care Unit. | Clinical outcome prediction for precision medicine | Marsh Königs |
| The BPD prediction Study | Frank Bennis developed a model that predicts the development of BPD (at 36 weeks) using routinely collected clinical data and continuous vital signs collected in the first 7 days after birth. The prediction model consists of an auto-encoder with long short-term memory model, embedded in a neural network. The model is currently implemented in EPIC for automatic outcome prediction and real-world model performance monitoring. | Clinical outcome prediction for precision medicine | Marsh Königs |
| The PEPR Study | Cece Kooper determines the added value of machine learning models to predict outcome based premorbid data, hospital data and multimodal MRI data assessing structural and functional brain connectivity. | Clinical outcome prediction for precision medicine | Marsh Königs |
| The ONSET Study | Noa Ijdo determines predictors of early adverse neurocognitive development in infants using with sickle cell disease | Clinical outcome prediction for precision medicine | Marsh Königs |
| The MATURE Study | Dook Koch determines predictors of very long-term term outcome of childhood meningitis in young adulthood. | Clinical outcome prediction for precision medicine | Marsh Königs |
| The Royal Dutch Football Association’s Concussion Clinic | The Royal Duthc Football Association's Concussion Clinic, supervised by Marloes Hoppen, is a combined clinical and research outpatient clinic for patients with persisting symptoms after sport-related concussion. The structured care path contributes to continuously expanding database for care evaluation and scientific research. The cohort involves more than 500 patients in 2025, representing the largest cohort of patients with persisting symptoms after sport-related concussion in Europe. Research based on this cohort is part of the Dutch Clinical Guidelines for care in this patient group. | Data-driven health care innovation | Marsh Königs |
| The Health Intelligence Program at the Daan Theeuwes Center for Intensive Neurorehabilitation | Ruud van der Veen aims to provide continuous care evaluation for young adults with severe brain injury. As part of this program, interprofessional data collection has been structured in a Measurement Feedback System. This clinical data is routinely measured as part of the primary care process, captured in an electronic patient data platform, directly fed back to the interdisciplinary team by individual patient dashboards and used as a basis for clinical decision-making by the interdisciplinary team meeting in cycles of 6 weeks. The structured data also flows into continuously expanding databases with longitudinal data tracking interdisciplinary recovery progress, used for a periodic cycle of care evaluation and scientific research aimed at the transition towards precision medicine. | Data-driven health care innovation | Marsh Königs |
| The PRIDICT-BPD study | Emma Baas and Michelle Romijn investigate the interplay between adrenocortical function and inflammation as predictor for BPD in extremely preterm infants. | The developing HPA axis | Martijn Finken |
| The HARDI study | Emma Baas investigates the developmental trajectory of cortisol production and diurnal rhythmicity across infancy. | The developing HPA axis | Martijn Finken |
| NOGBS | Marleen Groenveld contributes to this study 1) to investigate the clinical presentation, risk factors, and outcomes following GBS and E. coli infections in children under 3 months of age in the Netherlands, 2) to determine the genetic properties of the GBS bacterium that contribute to disease severity. 3) to compare protective antibodies against GBS among patients, healthy controls, and their mothers. This research will contribute to the further development of GBS vaccines 1) to investigate the clinical presentation, risk factors, and outcomes following GBS and E. coli infections in children under 3 months of age in the Netherlands, 2) to determine the genetic properties of the GBS bacterium that contribute to disease severity. 3) to compare protective antibodies against GBS among patients, healthy controls, and their mothers. This research will contribute to the further development of GBS vaccines, NOGBS study | Neuroinfections Amsterdam. | Paediatric IBD with focus on nutritional therapy | Merijn Bijlsma |
| IPACE-KIDS | Nina Groeneveld improves the causal diagnosis in patients suspected of neurological infections, | Paediatric IBD with focus on nutritional therapy | Merijn Bijlsma |
| EOScalcNL | Sanne Janssen contributes to this tailor-made Dutch neonatal early-onset sepsis calculator: towards precision medicine at birth | Paediatric IBD with focus on nutritional therapy | Merijn Bijlsma |
| Immunogenicity and Safety Assessment of an Earlier Prime and Boost Measles Vaccination Schedule in High Burden setting | Gerald Businge (Uganda) investigates immunogenicity and Safety Assessment of an Earlier Prime and Boost Measles Vaccination Schedule in High Burden setting | Paediatric IBD with focus on nutritional therapy | Merijn Bijlsma |
| Revestive monitor | Xavier Werner contributes to this prospective, observational, multicenter study to assess (cost)efficacy and safety of GLP-2 in children with short bowel syndrome. | Pediatric chronic intestinal failure | Merit Tabbers |
| Rivaroxoban in chronic intestinal failure | Xavier Werner and Samantha Gouw contribute to this prospective, observational study to evaluate pharmacokinetics of rivaroxaban in children with chronic intestinal failure. | Pediatric chronic intestinal failure | Merit Tabbers |
| Essential fatty acid deficiency | Xavier Werner andSuzanne van Zundert investigate essential fatty acid deficiency and neurocognitive development of children with chronic intestinal failure on home parenteral nutrition. | Pediatric chronic intestinal failure | Merit Tabbers |
| Nephropathology | Xavier Werner and Arend Bökenkamp investigate nephropathology in children with chronic intestinal failure on home parenteral nutrition: prospective, observational cohort study. | Pediatric chronic intestinal failure | Merit Tabbers |
| Unraveling the pathogenesis of microvillous inclusion disease(UD/UHD): development of organoids. | Unraveling the pathogenesis of microvillous inclusion disease(UD/UHD): development of organoids. | Pediatric chronic intestinal failure | Merit Tabbers |
| Microbiome and Tryptophan metabolites in children with intestinal failure +/- liver failure | Bruno Sovran and Annika Mutanen investigate microbiome and Tryptophan metabolites in children with intestinal failure +/- liver failure | Pediatric chronic intestinal failure | Merit Tabbers |
| Pediatric intestinal pseudo-obstruction syndrome in Europe | Annika Mutanen contribute to this prospective multicenter cohort study. | Pediatric chronic intestinal failure | Merit Tabbers |
| Efficacy and safety of Taurolodine locks after GI surgery | Adinda Pijpers and Xavier Werner contribute to this prospective observational study. | Pediatric chronic intestinal failure | Merit Tabbers |
| International Intestinal Failure registry | Xavier Werner contributes to this international, prospective registry for children with chronic intestinal failure on home parenteral nutrition. | Pediatric chronic intestinal failure | Merit Tabbers |
| Optimal catheter care in children on Home PN | Michiel Lagerweij: and Roel Bakxcontribute to this prospective cohort study | Pediatric chronic intestinal failure | Merit Tabbers |
| The NOGBS Study | Marleen Groenveld contributes to this study 1) to investigate the clinical presentation, risk factors, and outcomes following GBS and E. coli infections in children under 3 months of age in the Netherlands, 2) to determine the genetic properties of the GBS bacterium that contribute to disease severity. 3) to compare protective antibodies against GBS among patients, healthy controls, and their mothers. This research will contribute to the further development of GBS vaccines | Paediatric IBD with focus on nutritional therapy | Michaël Boele van Hensbroek |
| IPACE-KIDS | Nina Groeneveld improves the causal diagnosis in patients suspected of neurological infections | Paediatric IBD with focus on nutritional therapy | Michaël Boele van Hensbroek |
| EOScalcNL | Sanne Janssen contributes to this tailor-made Dutch neonatal early-onset sepsis calculator: towards precision medicine at birth, | Paediatric IBD with focus on nutritional therapy | Michaël Boele van Hensbroek |
| Immunogenicity and Safety Assessment of an Earlier Prime and Boost Measles Vaccination Schedule in High Burden setting | Gerald Businge (Uganda) investigates immunogenicity and Safety Assessment of an Earlier Prime and Boost Measles Vaccination Schedule in High Burden setting | Paediatric IBD with focus on nutritional therapy | Michaël Boele van Hensbroek |
| Data mining study into undiagnosed patients | Bregje Jaeger contributes to this recent study | Riboflavin Transporter Deficiency | Nicole Wolf |
| Evaluation of effectiveness of Riboflavin in patients with inborn errors of metabolism | recent | Riboflavin Transporter Deficiency | Nicole Wolf |
| Patient registry (Context of Metab ERN ECZA) | planned | Riboflavin Transporter Deficiency | Nicole Wolf |
| Treatment optimization | planned | Riboflavin Transporter Deficiency | Nicole Wolf |
| Omics studies into optimal biomarkers | planned | Riboflavin Transporter Deficiency | Nicole Wolf |
| Amsterdam Cohort of Gender Dysphoria (ACOG) study | Lidewij Boogers contributes to this retrospective cohort study investigating the efficacy and safety of hormonal treatment in transgender adolescents. | Evaluation of hormonal treatment in transgender adolescents | Sabina Hannema |
| The ENIGI adolescents study | Lidewij Boogers and Isabelle van der Meulen contribute to this international prospective cohort study that evaluates the effects and side effects of hormonal treatment in transgender adolescents, combining various clinical measurements with questionnaires to assess satisfaction with treatment. | Evaluation of hormonal treatment in transgender adolescents | Sabina Hannema |
| Long-term safety of gonadotropin releasing hormone analogue treatment in transgender adolescents | Gillian Schuurman uses data from a national registry (CBS) to assess somatic and mental health as well as educational and socioeconomic outcomes in transgender individuals that received GnRH analogue treatment in adolescence and will compare outcomes to a control group that did not receive GnRH analogue treatment. | Evaluation of hormonal treatment in transgender adolescents | Sabina Hannema |
| Does transdermal rather than oral estradiol treatment improve efficacy of growth hormone treatment? | Lieve Willemsen uses data from the Dutch Registry Growth Hormone treatment to compare oral and estradiol treatment in girls with Turner syndrome. | Improving care for children and adolescents with a difference of sex development (DSD) | Sabina Hannema |
| Follow Me programme for children and adolescents with DSD | Maaike Kroon and Lieve Willemsen contribute to a Follow Me programme for children and adolescents with DSD has been established to allow Continuous data-driven health care innovation | Improving care for children and adolescents with a difference of sex development (DSD) | Sabina Hannema |
| The MASK FIT Studies | Rosemijne Pigmans investigates personalization of pediatric ventilation masks by 3D scanning & printing | Pediatric acute lung injury and respiratory support | Suzanne Terheggen |
| The PROVENT-PED Studies | Jonathan Melger and Relin van Vliet investigate global practice of pediatric ventilation and respiratory support | Pediatric acute lung injury and respiratory support | Suzanne Terheggen |
| The POWER Studies | Thijs Lilien and Agnes Maas investigate chemical energy (power) transfer by hyperoxia treatment and mechanical ventilation. | Pediatric acute lung injury and respiratory support | Suzanne Terheggen |
| The RHEOMUCUS Studies | Rosalie Linssen investigates biophysical properties of airway mucus in ICU patients | Pediatric acute lung injury and respiratory support | Suzanne Terheggen |
| NK CAR cells for cancer treatment: functionality and production. | NK CAR cells for cancer treatment: functionality and production. | Pediatric Immunology | Taco Kuijpers |
| T2B-iCARE | This study investigates when to apply novel immune therapies – including CART - in B-cell immune-mediated disorders | Pediatric Immunology | Taco Kuijpers |
| BTHS iPSC neutrophil development | BTHS iPSC neutrophil development | Pediatric Immunology | Taco Kuijpers |
| Neutrophil extracellular trap formation (NETs): mechanisms of action | Neutrophil extracellular trap formation (NETs): mechanisms of action | Pediatric Immunology | Taco Kuijpers |
| Role of neutrophil activation and cell death by NET formation in TRALI | Role of neutrophil activation and cell death by NET formation in TRALI | Pediatric Immunology | Taco Kuijpers |
| Autoimmune disease: imbalances with a signature (Immune Health Seed) | Autoimmune disease: imbalances with a signature (Immune Health Seed) | Pediatric Immunology | Taco Kuijpers |
| Inborn errors of immunity: molecular mechanisms, NFkB activation and interferonopathies. | Inborn errors of immunity: molecular mechanisms, NFkB activation and interferonopathies. | Pediatric Immunology | Taco Kuijpers |
| Kawasaki Disease | Kawasaki Disease | Pediatric Immunology | Taco Kuijpers |
| DIAMONDS | Pediatric Immunology | Taco Kuijpers | |
| Prediction of late onset sepsis and NEC by microbiota profiling and metabolomics | Rimke de Kroon investigates prediction of late onset sepsis and NEC by microbiota profiling and metabolomics | Generation P: Microbiome and pediatric gut health | Tim de Meij |
| Implementation of ispro as microbiome analytical technique in clinical practice | Rimke de Kroon contributes to implementation of ispro as microbiome analytical technique in clinical practice | Generation P: Microbiome and pediatric gut health | Tim de Meij |
| Neonatal gut health and role of fungi | Rimke de Kroon investigates neonatal gut health and role of fungi | Generation P: Microbiome and pediatric gut health | Tim de Meij |
| Effects of amnion fluid composition on neonatal gut health and microbiome colonization | Rimke de Kroon investigates effects of amnion fluid composition on neonatal gut health and microbiome colonization | Generation P: Microbiome and pediatric gut health | Tim de Meij |
| Probiotics and microbiome in preterm infants | Aranka van Wesemael investigates probiotics and microbiome in preterm infants | Generation P: Microbiome and pediatric gut health | Tim de Meij |
| Effects of antibiotics on microbial colonization | Aranka van Wesemael investigates effects of antibiotics on microbial colonization | Generation P: Microbiome and pediatric gut health | Tim de Meij |
| Probiotics and health outcomes: a nationwide cohort study | Aranka van Wesemael investigates probiotics and health outcomes: a nationwide cohort study | Generation P: Microbiome and pediatric gut health | Tim de Meij |
| Microbiome and antibiotics: effects on health outcomes beyond infancy | Nina Ferichs investigates Microbiome and antibiotics: effects on health outcomes beyond infancy | Generation P: Microbiome and pediatric gut health | Tim de Meij |
| Generation P: Feeding pattern and growth in preterm infants beyond neonatal period | Nina Ferichs investigates Generation P: Feeding pattern and growth in preterm infants beyond neonatal period | Generation P: Microbiome and pediatric gut health | Tim de Meij |
| Tryptophan metabolites determination as diagnostic tool for gram-negative late-onset sepsis in preterm infants | Nina Ferichs investigates tryptophan metabolites determination as diagnostic tool for gram-negative late-onset sepsis in preterm infants | Generation P: Microbiome and pediatric gut health | Tim de Meij |
| Development of a molecular point-of-care test to early detect microbes in blood samples | Jip Groen develops a molecular point-of-care test to early detect microbes in blood samples | Generation P: Microbiome and pediatric gut health | Tim de Meij |
| The correlation between gut microbes and metabolomics in de novo pediatric IBD, related to disease outcome | Eva Vermeer investigates the correlation between gut microbes and metabolomics in de novo pediatric IBD, related to disease outcome | Microbiome and metabolome in pediatric IBD Therapeutic drug monitoring in MTX | Tim de Meij |
| Cancer surveillance in pediatric IBD | Eva Vermeer investigates cancer surveillance in pediatric IBD | Microbiome and metabolome in pediatric IBD Therapeutic drug monitoring in MTX | Tim de Meij |
| Therapeutic drug monitoring of MTX in pediatric IBD | Laura Verstoep investigates therapeutic drug monitoring of MTX in pediatric IBD | Microbiome and metabolome in pediatric IBD Therapeutic drug monitoring in MTX | Tim de Meij |
| Fecal metabolomics as adjuvant noninvasive biomarker in pediatric IBD | Laura Verstoep investigates fecal metabolomics as adjuvant noninvasive biomarker in pediatric IBD | Microbiome and metabolome in pediatric IBD Therapeutic drug monitoring in MTX | Tim de Meij |
| Profiling the landscape of child and adolescent psychiatry | Profiling the landscape of child and adolescent psychiatry | DREAMS (Dutch REsearch in child and Adolescent Mental health) | Tinca Polderman |
| Medication use in child and adolescent psychiatry | Medication use in child and adolescent psychiatry | DREAMS (Dutch REsearch in child and Adolescent Mental health) | Tinca Polderman |
| Effects of the COVID-19 pandemic on mental health problems in youth | Effects of the COVID-19 pandemic on mental health problems in youth | DREAMS (Dutch REsearch in child and Adolescent Mental health) | Tinca Polderman |
| The SOS BPD Study | Rosemarie de Ridder investigates the optimal lower limit saturation in infants with established BPD. | Bronchopulmonary dysplasia | Wes Onland |
| The PRIDICT BPD study | Emma Baas investigates the discriminating accuracy of biomarkers in blood and exhaled breath for the prediction of BPD in a multicenter setting. | Bronchopulmonary dysplasia | Wes Onland |
| The BPD diagnosis study | Trix Katz investigates what is the optimal definition of BPD in an international collaboration. | Bronchopulmonary dysplasia | Wes Onland |
| The Long term follow-up of the SToPBPD trial | Moniek van de Loo investigates the long term outcomes of the placebo controlled trial of hydrocortisone in preterm infants. | Bronchopulmonary dysplasia | Wes Onland |
| Cerebral Palsy in low-resource settings | Bente van der Meijden(Malawi) investigates both qualitative (health-related quality of life, stigma) as quantitative (nutritional status, swallowing disorders) aspects of children and their caregivers in Malawi. | Malnutrition in childhood | Wieger Voskuijl |
| Under 6 months malnutrition in Yemen | Maha Basodan (Yemen) assesses prevalence, associated factors and outcomes in 2 provinces in Yemen. | Malnutrition in childhood | Wieger Voskuijl |
| Pediatric post-discharge care in low-resource settings | Johnstone Thitiri (Kenya) analyses all aspects of the discharge process in hospitalised children and the relation with post-discharge outcomes | Malnutrition in childhood | Wieger Voskuijl |
| Post-discharge mortality and risk prediction using clinical warning signs | Carolyn Briody (Finland) assesses prevalence and risk factors for pediatric post-discharge mortality (1) and the use of clinical warning signs for triage and risk prediction in hospitalised children are analysed (2). | Malnutrition in childhood | Wieger Voskuijl |
| The impact of climate change on the burden of pathogen-specific diarrheal disease | The impact of climate change on the burden of pathogen-specific diarrheal disease (Frederike Kooiman, The Netherlands). Co-supervision with dr Vanessa Harris (Amsterdam UMC) | Malnutrition in childhood | Wieger Voskuijl |
| The QoL Study | Study in children and adults with homozygous FH | Familial Hypercholesterolemia | Willemijn Corpeleijn |
| Follow-up of a large cohort of adults who were diagnosed with FH as children | Sibbeliene van den Bosch contributes to a follow-up of a large cohort of adults who were diagnosed with FH as children (PhD: Sibbeliene vd Bosch) | Familial Hypercholesterolemia | Willemijn Corpeleijn |
| Cascade screening for high Lp(a) | Sibbeliene van den Bosch investigates cascade screening for high Lp(a) | Familial Hypercholesterolemia | Willemijn Corpeleijn |
| cIMT measurements in the doctor’s office | Sibbeliene van den Bosch and F. Kowsoleea investigate cIMT measurements in the doctor’s office | Familial Hypercholesterolemia | Willemijn Corpeleijn |
| Incidence of statin intolerance in childhood | Sibbeliene van den Bosch and F. Kowsoleea investigate the incidence of statin intolerance in childhood | Familial Hypercholesterolemia | Willemijn Corpeleijn |
Last edited: 05-03-2026